Difference between revisions of "Part:BBa K3351006"

Revision as of 13:12, 19 October 2020

P5, an antimicrobial peptide

P5 (RIVQRIKKWLLKWWKLGY) is a synthetic cationic 18aa peptide. The outer cell membrane of gram-negative bacteria contains negatively charged lipopolysaccharide (LPS). Antimicrobial peptides can replace divalent cations such as Mg2+ and Ca2+ bound to LPS, causing the outer membrane to rupture or perforate and penetrate the outer membrane. The antimicrobial peptides penetrating the outer membrane and the negatively charged phospholipids on the inner cell membrane are combined by electrostatic attraction, and they are inserted into the phospholipid layer through hydrophobic interaction, forming a cavity or temporary channel on the cell membrane, causing the cell membrane to collapse (felt model) or making it antibacterial The peptide penetrates the cell membrane (barrel plate model).

Sequence and Features