Difference between revisions of "Part:BBa K3351003"

Revision as of 13:06, 19 October 2020

DCD1L, an antimicrobial peptide.

Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. The anionic derivative, DCD-1L, comprises of the N-terminal 47 residues of DCD and one additional leucine residue. DCD-1L is anionic, with a net charge of −5, and is amphipathic in nature. It has three helical regions and its cationic N-terminal part is proposed to interact with negatively charged phospholipid membranes of bacteria. On the bacterial membrane, studies suggest that the DCD-1L peptide first aligns flat with surface and then slowly forms oligomeric complexes, which are stabilized by Zn2+ and coordinated by the H38 residue. The oligomeric complex then breaks open, inserts into the membrane, and undergoes re-oligomerization to form the channel. The contents flow out though the channel and the bacterial die.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

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 <partinfo>BBa_K3351003 short</partinfo>
-It is coding sequence of  DCD1L.
+Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. The anionic derivative, DCD-1L, comprises of the N-terminal 47 residues of DCD and one additional leucine residue. DCD-1L is anionic, with a net charge of −5, and is amphipathic in nature. It has three helical regions and its cationic N-terminal part is proposed to interact with negatively charged phospholipid membranes of bacteria. On the bacterial membrane, studies suggest that the DCD-1L peptide first aligns flat with surface and then slowly forms oligomeric complexes, which are stabilized by Zn2+ and coordinated by the H38 residue. The oligomeric complex then breaks open, inserts into the membrane, and undergoes re-oligomerization to form the channel. The contents flow out though the channel and the bacterial die.
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