Difference between revisions of "Part:BBa K3011012"
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| − | + | We used the cytoplasmic domain of Human Copper Transporter (hCtr1) as an analogue of the metal ion chelator. hCtr1 transports copper with high affinity in a time-dependent and saturable manner and is metal-specific. hCtr1-mediated copper transport is an energy-independent process and is stimulated by extracellular acidic pH and high K(+) concentrations. hCtr1 exists as a homomultimer at the plasma membrane in mammalian cells. The part that we are using for our experimental purposes consists of only two domains that can bind ions. | |
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Revision as of 18:52, 21 October 2019
Metal ion Chelator
We used the cytoplasmic domain of Human Copper Transporter (hCtr1) as an analogue of the metal ion chelator. hCtr1 transports copper with high affinity in a time-dependent and saturable manner and is metal-specific. hCtr1-mediated copper transport is an energy-independent process and is stimulated by extracellular acidic pH and high K(+) concentrations. hCtr1 exists as a homomultimer at the plasma membrane in mammalian cells. The part that we are using for our experimental purposes consists of only two domains that can bind ions.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]