Difference between revisions of "Part:BBa K2978101"

 
 
(3 intermediate revisions by the same user not shown)
Line 3: Line 3:
 
<partinfo>BBa_K2978101 short</partinfo>
 
<partinfo>BBa_K2978101 short</partinfo>
  
−
left
+
AgrB protein is part of the quorum sensing system of <i>Clostridioides difficile</i>, specifically this transmembrane protein process and transform the [[Part:BBa_K2978105|AgrD peptide]] into an auto inducer protein that is the responsible for the QS activation in the pathogen.
 +
<br>
 +
The function and mechanism of this quorum sensing is not well described yet. Moreover, previous analysis of the pathogen genome shows that this sequence is homologous to the accessory gene regulatory (agr) operon, present in many Gram-positive bacteria, including <i>S. aureus</i>, bacteria which we based many of the functions of the proteins and let us hypothesize a way to treat the infection.
 +
<br>
 +
This accession refers to a <i>de novo</i> synthesis, a basic part of the composite part [[Part:BBa_K2978100| BBa_K2978100]], which has been evaluated in response of the modification of the behavior of the pathogen.
  
−
<!-- Add more about the biology of this part here
 
 
===Usage and Biology===
 
===Usage and Biology===
 +
This gene is not  present in all strains of <i>C. diff</i>. Even though, mostly of strains known should be susceptible to the inducer, because they posses the receptors proteins that sense this AIP.
  
−
<!-- -->
 
 
<span class='h3bb'>Sequence and Features</span>
 
<span class='h3bb'>Sequence and Features</span>
 
<partinfo>BBa_K2978101 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K2978101 SequenceAndFeatures</partinfo>

Latest revision as of 06:41, 18 October 2019


AgrB Clostridioides difficile gene

AgrB protein is part of the quorum sensing system of Clostridioides difficile, specifically this transmembrane protein process and transform the AgrD peptide into an auto inducer protein that is the responsible for the QS activation in the pathogen.
The function and mechanism of this quorum sensing is not well described yet. Moreover, previous analysis of the pathogen genome shows that this sequence is homologous to the accessory gene regulatory (agr) operon, present in many Gram-positive bacteria, including S. aureus, bacteria which we based many of the functions of the proteins and let us hypothesize a way to treat the infection.
This accession refers to a de novo synthesis, a basic part of the composite part BBa_K2978100, which has been evaluated in response of the modification of the behavior of the pathogen.

Usage and Biology

This gene is not present in all strains of C. diff. Even though, mostly of strains known should be susceptible to the inducer, because they posses the receptors proteins that sense this AIP.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 370
  • 1000
    COMPATIBLE WITH RFC[1000]