Difference between revisions of "Part:BBa K3182005"

Revision as of 15:48, 14 September 2019

LL-37

Homo sapiens antimicrobial peptide, designed to target bacteria. This part was designed to be assembled with BBa_K3182100. LL37 is normally found within the lysosome of macrophages and is used to puncture the cell membrane of bacteria.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

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 <partinfo>BBa_K3182005 short</partinfo>
-Homo sapiens antimicrobial peptide, designed to target bacteria. This part was designed to be assembled with BBa_K3182100.
+Homo sapiens antimicrobial peptide, designed to target bacteria. This part was designed to be assembled with BBa_K3182100. LL37 is normally found within the lysosome of macrophages and is used to puncture the cell membrane of bacteria.
-[[File:T--Linkoping_Sweden--MechofAction.png|650px|thumb|center|<b>Figure 1.</b> General mechanism of action when the antimicrobial agent is fused to BBa_K3182010 which contains the linker, thrombin site and cellulose binding domain. The cellulose binding domain enables the attachment of antimicrobial agents (such as antimicrobial peptide or enzyme) to the cellulose. This also inactivates the agents when they are expressed in its bacterial host. Later, when the bandage comes in contact with thrombin in the blood, the antimicrobial agents will be activated upon cleavage of its thrombin site.]]
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