Difference between revisions of "Part:BBa K2976000"
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Toll-like receptor 1 (TLR1) is a transmembrane glycoprotein that participates in the innate immune response to microbial agents. TLR1 could form active heterodimers with TLR2 when exposed to some pathogen-associated molecular pattern molecules (PAMPs), and the heterodimers recognize plenty of substances in lipoarabinomannan (LAM) biosynthesis with the help of CD14. | Toll-like receptor 1 (TLR1) is a transmembrane glycoprotein that participates in the innate immune response to microbial agents. TLR1 could form active heterodimers with TLR2 when exposed to some pathogen-associated molecular pattern molecules (PAMPs), and the heterodimers recognize plenty of substances in lipoarabinomannan (LAM) biosynthesis with the help of CD14. | ||
| − | ==Usage== | + | ===Usage=== |
<p>In 2019 CPU_CHINA project, TLR1 is expressed along with TLR2 and CD14 to form the TLR2:TLR1:CD14 cluster on the designer cell membrane. As a Mtb sensor, the complex could recognize the substances of Mtb and then stimulate the downstream signaling pathway. Then, activated NF-κB initiates transcription of the gene circuits to express other proteins in our project.</p> | <p>In 2019 CPU_CHINA project, TLR1 is expressed along with TLR2 and CD14 to form the TLR2:TLR1:CD14 cluster on the designer cell membrane. As a Mtb sensor, the complex could recognize the substances of Mtb and then stimulate the downstream signaling pathway. Then, activated NF-κB initiates transcription of the gene circuits to express other proteins in our project.</p> | ||
| − | ==Biology== | + | ===Biology=== |
Revision as of 01:12, 6 June 2019
Toll-like receptor 1
Toll-like receptor 1 (TLR1) is a transmembrane glycoprotein that participates in the innate immune response to microbial agents. TLR1 could form active heterodimers with TLR2 when exposed to some pathogen-associated molecular pattern molecules (PAMPs), and the heterodimers recognize plenty of substances in lipoarabinomannan (LAM) biosynthesis with the help of CD14.
Usage
In 2019 CPU_CHINA project, TLR1 is expressed along with TLR2 and CD14 to form the TLR2:TLR1:CD14 cluster on the designer cell membrane. As a Mtb sensor, the complex could recognize the substances of Mtb and then stimulate the downstream signaling pathway. Then, activated NF-κB initiates transcription of the gene circuits to express other proteins in our project.
Biology
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]