Difference between revisions of "Part:BBa K2588006"

 
 
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<p>CbtA is a cytoskeleton toxin expressed by <i>E. coli</i>. It is the third part in our growth inhibition module. We decided to use this component of the type IV toxin-antitoxin system, because it interacts with FtsZ and MreB. Both proteins are involved in the elongation of <i>E. coli</i> during cell division as well as for building of the F-ring, to divide the cell.</p>
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<h2>Usage and Biology</h2>
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<p>CbtA inhibits the polymerization of FtsZ and MreB by binding to them and therefore inhibits cell division.<sup>1</sup>
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<h2>References</h2>
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<li>Tan, Q., Awano, N. & Inouye, M. YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB. <i>Mol. Microbiol</i>. <b>79</b>, 109–118 (2011).</li>
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Latest revision as of 01:49, 18 October 2018


Cell division inhibitor cbtA

CbtA is a cytoskeleton toxin expressed by E. coli. It is the third part in our growth inhibition module. We decided to use this component of the type IV toxin-antitoxin system, because it interacts with FtsZ and MreB. Both proteins are involved in the elongation of E. coli during cell division as well as for building of the F-ring, to divide the cell.

Usage and Biology

CbtA inhibits the polymerization of FtsZ and MreB by binding to them and therefore inhibits cell division.1

References

  1. Tan, Q., Awano, N. & Inouye, M. YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB. Mol. Microbiol. 79, 109–118 (2011).

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]