Revision as of 15:50, 23 July 2008

Antibiotic Resistance Parts

Introduction to Antibiotic Resistance

The established mechanisms of antibiotic resistance include the following: (1.) Enzymes that inactivate the antibiotic [famously (a). beta-lactamases that destroy penicillins and related compounds and (b) enzymes that acetylate chloramphenicol]. (2.) Proteins that keep antibiotics from entering the cell (by blocking the outer-membrane pores). (3) Membrane-embedded channel proteins that actively pump antibiotics out of the cell. (4.) Proteins (and RNAs?) with altered drug binding sites. (Vancomycin resistance comes from a switch in the chemistry of the cell-wall cross-linking peptide). This category also includes mutations in ribosomal RNA -- ribosomes are one of the main targets of both prokaryote- and eukaryote-directed antibiotics. (5.) Proteins that enable substitution of an alternative metabolic pathway (as in the case of sulfonamide resistance).

Parts by Category

1. Antibiotic-inactivating Enzymes

2. Membrane-blocking Proteins

3. Membrane-embedded Efflux Pumps

4. Altered Target Molecules

5. Components of Alternative Metabolic Pathways

Useful Information about Antibiotic Resistance

Links

http://www.antibioresistance.be/aminoglycosides.html