Difference between revisions of "User:Scmohr/Antibiotic-res cat page"

(New page: The established mechanisms of antibiotic resistance include the following:)
 
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=Antibiotic Resistance Parts=
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==Introduction to Antibiotic Resistance==
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The established mechanisms of antibiotic resistance include the following:
 
The established mechanisms of antibiotic resistance include the following:
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  1. Enzymes that inactivate the antibiotic [famously (a). beta-lactamases that destroy penicillins and related compounds and (b) enzymes that acetylate chloramphenicol].
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  2. Proteins that keep antibiotics from entering the cell (by blocking the outer-membrane pores), or actively pump them out after they enter.
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  3. Alteration of the drug binding site (vancomycin resistance comes from a switch in the chemistry of the cell-wall cross-linking peptide). This category also includes mutations in ribosomal RNA.
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  4. Substitution of an alternative metabolic pathway (as in the case of sulfonamide resistance).
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==Parts by Category==
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===1. Antibiotic-inactivating Enzymes===
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===2. Membrane-blocking Proteins===
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===3. Membrane-embedded Efflux Pumps===
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===4. Altered Target Molecules===
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===5. Components of Altered Metabolic Pathways===

Revision as of 15:00, 23 July 2008

Antibiotic Resistance Parts

Introduction to Antibiotic Resistance

The established mechanisms of antibiotic resistance include the following: 

 1. Enzymes that inactivate the antibiotic [famously (a). beta-lactamases that destroy penicillins and related compounds and (b) enzymes that acetylate chloramphenicol].

  2. Proteins that keep antibiotics from entering the cell (by blocking the outer-membrane pores), or actively pump them out after they enter.

  3. Alteration of the drug binding site (vancomycin resistance comes from a switch in the chemistry of the cell-wall cross-linking peptide). This category also includes mutations in ribosomal RNA.

  4. Substitution of an alternative metabolic pathway (as in the case of sulfonamide resistance).

Parts by Category

1. Antibiotic-inactivating Enzymes

2. Membrane-blocking Proteins

3. Membrane-embedded Efflux Pumps

4. Altered Target Molecules

5. Components of Altered Metabolic Pathways