Difference between revisions of "Part:BBa K2653014"

Revision as of 12:21, 17 October 2018

VEGF

The single-chain variable fragments(scFv)of VEGF.

Usage and Biology

VEGF was first identified in guinea pigs, hamsters, and mice by Senger et al. in 1983.1 VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body.

Sequence and Features