Difference between revisions of "Part:BBa K2632008"

 
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<partinfo>BBa_K2632008 short</partinfo>
 
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RGD is a well-studied tumor homing peptide on the external loop of outer membrane protein A (OmpA). OmpA with RGD sequence can specifically binds to alpha v beta 3 (&#945;v&#946;3) integrin, so that the RGD-displaying Salmonella can strongly bound to cancer cells overexpress &#945;v&#946;3, which improve the targeting of our Salmonella to target tumor cells. 1The OmpA sequence of E.coli is different from that one of Salmonella, which lost 17 amino acids in 132 site.
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RGD is a well-studied tumor homing peptide on the external loop of outer membrane protein A (OmpA). OmpA with RGD sequence can specifically binds to alpha v beta 3 (αvβ3) integrin, so that the RGD-displaying Salmonella can strongly bound to cancer cells overexpress αvβ3, which improve the targeting of our Salmonella to target tumor cells. 1The OmpA sequence of E.coli is different from that one of Salmonella, which lost 17 amino acids in 132 site.
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<h3>Reference</h3>
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<p>
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Park, S. H. et al. RGD peptide cell-surface display enhances the targeting and therapeutic efficacy of attenuated salmonella-mediated cancer therapy. Theranostics 6, 1672–1682 (2016).</p>
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===Usage and Biology===
 
===Usage and Biology===
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Revision as of 12:03, 16 September 2018

Plac-Lpp-OmpA-RGD

RGD is a well-studied tumor homing peptide on the external loop of outer membrane protein A (OmpA). OmpA with RGD sequence can specifically binds to alpha v beta 3 (αvβ3) integrin, so that the RGD-displaying Salmonella can strongly bound to cancer cells overexpress αvβ3, which improve the targeting of our Salmonella to target tumor cells. 1The OmpA sequence of E.coli is different from that one of Salmonella, which lost 17 amino acids in 132 site.

Reference

Park, S. H. et al. RGD peptide cell-surface display enhances the targeting and therapeutic efficacy of attenuated salmonella-mediated cancer therapy. Theranostics 6, 1672–1682 (2016).

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]