Difference between revisions of "Part:BBa K2309026"

Latest revision as of 12:13, 1 November 2017

Komodo dragon-inspired synthetic peptide DRGN-1 for Lactococcus lactis Inspired by a histone H1-derived peptide from the Komodo dragon (Varanus komodoensis), called VK25. a synthetic peptide called DRGN-1 was designed to show the remarkable anti-biofilm activity against Pseudomonas aeruginosa and Staphylococcus aureus. Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm ( Pseudomonas aeruginosa and Staphylococcus aureus).

Usage and Biology

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

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 __NOTOC__
 <partinfo>BBa_K2309026 short</partinfo>
+Inspired by a histone H1-derived peptide from the Komodo dragon (Varanus komodoensis), called VK25. a synthetic peptide called DRGN-1 was designed to show the remarkable anti-biofilm activity against <i> Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>. Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm (<i> Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>).
-The novel synthetic peptide DRGN-1 (inspired by a peptide identified from Komodo dragon) exhibits pathogen-directed and host-directed activities in promoting the clearance and healing of polymicrobial (Pseudomonas aeruginosa & Staphylococcus aureus) biofilm infected wounds. We considered it initially as one of  our antimicrobial peptides.
+https://static.igem.org/mediawiki/parts/d/d0/DRGN-1_XJTLU-CHINA.png
-A histone H1-derived peptide from the Komodo dragon (Varanus komodoensis)were defined as VK25. a synthetic peptide called DRGN-1 were designed based on VK-25. DRGN-1 has anti-biofilm activity of both peptides against Pseudomonas aeruginosa and Staphylococcus aureus rather than VK-25.Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm (Pseudomonas aeruginosa and Staphylococcus aureus)-infected murine wounds.
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