Difference between revisions of "Part:BBa K2309026"
 
(One intermediate revision by the same user not shown)
Line 2: Line 2:
 
__NOTOC__
 
__NOTOC__
 
<partinfo>BBa_K2309026 short</partinfo>
 
<partinfo>BBa_K2309026 short</partinfo>
 +
Inspired by a histone H1-derived peptide from the Komodo dragon (Varanus komodoensis), called VK25. a synthetic peptide called DRGN-1 was designed to show the remarkable anti-biofilm activity against <i> Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>. Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm (<i> Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>).
  
−
The novel synthetic peptide DRGN-1 (inspired by a peptide identified from Komodo dragon) exhibits pathogen-directed and host-directed activities in promoting the clearance and healing of polymicrobial (Pseudomonas aeruginosa & Staphylococcus aureus) biofilm infected wounds. We considered it initially as one of  our antimicrobial peptides.
+
https://static.igem.org/mediawiki/parts/d/d0/DRGN-1_XJTLU-CHINA.png
  
−
A histone H1-derived peptide from the Komodo dragon (Varanus komodoensis)were defined as VK25. a synthetic peptide called DRGN-1 were designed based on VK-25. DRGN-1 has anti-biofilm activity of both peptides against Pseudomonas aeruginosa and Staphylococcus aureus rather than VK-25.Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm (Pseudomonas aeruginosa and Staphylococcus aureus)-infected murine wounds.
+
<!-- Add more about the biology of this part here-->
−
<!-- Add more about the biology of this part here
+
 
===Usage and Biology===
 
===Usage and Biology===
  

Latest revision as of 12:13, 1 November 2017


Komodo dragon-inspired synthetic peptide DRGN-1 for Lactococcus lactis Inspired by a histone H1-derived peptide from the Komodo dragon (Varanus komodoensis), called VK25. a synthetic peptide called DRGN-1 was designed to show the remarkable anti-biofilm activity against Pseudomonas aeruginosa and Staphylococcus aureus. Wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm ( Pseudomonas aeruginosa and Staphylococcus aureus).

DRGN-1_XJTLU-CHINA.png

Usage and Biology

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]