Difference between revisions of "Part:BBa K2374007"
Line 3: Line 3:
 
<partinfo>BBa_K2374007 short</partinfo>
 
<partinfo>BBa_K2374007 short</partinfo>
  
−
ple (Tyrosine 3-monooxygenase, TH)
+
'''ple''' (Tyrosine 3-monooxygenase, TH)
 +
 
 +
'''ple''' (TH) is a rate-limiting enzyme in the dopamine’s synthesis, and it plays an important role in the physiology of adrenergic neurons.
 +
'''Catalytic activity''':
 +
L-tyrosine + tetrahydrobiopterin + O2 = L-dopa + 4a-hydroxytetrahydrobiopterin.<br>
 +
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of catecholamine biosynthesis.<br>
 +
 
  
 
[[File:2017tongji_registry_image_dopa.png|center|500px|dopa]]  
 
[[File:2017tongji_registry_image_dopa.png|center|500px|dopa]]  

Revision as of 17:22, 31 October 2017


UAS-TH -> (fruit fly)

ple (Tyrosine 3-monooxygenase, TH)

ple (TH) is a rate-limiting enzyme in the dopamine’s synthesis, and it plays an important role in the physiology of adrenergic neurons. Catalytic activity: L-tyrosine + tetrahydrobiopterin + O2 = L-dopa + 4a-hydroxytetrahydrobiopterin.
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of catecholamine biosynthesis.


dopa

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 13
    Illegal PstI site found at 256
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 13
    Illegal PstI site found at 256
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 1540
    Illegal XhoI site found at 672
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 13
    Illegal PstI site found at 256
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 13
    Illegal PstI site found at 256
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 918
    Illegal BsaI site found at 1884
    Illegal BsaI.rc site found at 636
    Illegal BsaI.rc site found at 1402
    Illegal BsaI.rc site found at 1551