Difference between revisions of "Part:BBa K2302004"

Revision as of 10:28, 27 October 2017

L-FABP,a protein that can bind long chain fatty acids.

This sequence encodes a functional protein, liver fatty acid binding protein (L-FABP), which is one of fatty acid binding proteins with a molecular weight of 14-15 kDa.[1] It can reversibly bind long chain fatty acids with hydrogen bond. Its structure consists of two β-sheets, capped by a helix-turn-helix motif. The β-strands are organized into a β-barrel configuration, forming a clam-like structure that encloses a large solvated cavity to form a ligand binding site.[2]FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids (LCFAs), endocannabinoids, phytocannabinoids, synthetic cannabinoid receptor (CBR) agonists and antagonists, and other hydrophobic molecules.[3]

Sequence and Features