Difference between revisions of "Part:BBa K2298000"

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Human basic fibroblast growth factor (bFGF)

Biology and Usage

Fibroblast growth factors(FGFs), originally known for their capability of promoting fibroblast proliferation, are a family of growth factors that has shown great potentials on tissue repair. Human FGFs consist of 22 members. FGFs exert their roles by binding to the transmembrane tyrosine kinase receptors, FGF receptors(FGFRs), therefore triggering downstream signaling cascades including RAS/MAP Kinase pathway, PI3 Kinase/AKT pathway and PLC-gamma pathway. The signaling then stimulates a wide range of cellular responses, such as cell proliferation, cell migration, cell differentiation and angiogenesis. (see review【1】)

Due to the ability to induce fibroblast proliferation and angiogenesis, FGFs have been studied extensively in terms of tissue repair in diverse kinds of tissue, with basic fibroblast growth factor(bFGF) being the most used FGF in wound healing(see review【1】). bFGF is thought to be an initiator of the wound healing process, reaching its highest concentration soon after injury and then declining to serum level【2】. bFGF may also possess the anti-scarring effect during wound healing【3】, which makes it an potential candidate for scar-free healing applications.

Sequence and Features