Difference between revisions of "Part:BBa K1813003"
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<h2>Background of <i>CYP6CM1vQ</i></h2>
 
<h2>Background of <i>CYP6CM1vQ</i></h2>
  
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As a neonicotinoid pesticide, imidacloprid kills insects by irreversibly binding to nicotinic acetyl choline receptors, heavily interfering with neuronal transmission which can kill an insect at high doses. Due to this high level of specificity however mechanisms of resistance have evolved most notably in the whitefly, spurring the evolution of this variant of CYP6CM1. Capable of hydroxylating the 5th carbon of imidacloprid faster than other variants, CYP6CM!vQ bestows a partially protective effect against imidacloprid for an organism harboring this gene [1].
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As a neonicotinoid pesticide, imidacloprid kills insects by irreversibly binding to nicotinic acetyl choline receptors, heavily interfering with neuronal transmission which can kill an insect at high doses. Due to this high level of specificity however mechanisms of resistance have evolved, most notably in the whitefly, possessing this variant of CYP6CM1. Capable of hydroxylating the 5th carbon of imidacloprid faster than other variants, CYP6CM!vQ bestows a partially protective effect against imidacloprid for an organism harboring this gene [1].
  
  

Revision as of 02:38, 18 September 2015

CYP6CM1

CYP6CM1: Coding sequence of CYP6CM1vQ, an Cytochrome p450 enzyme from the Q population of Bemisia tabaci, hydroxylating the 5C of imidacloprid.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Background of CYP6CM1vQ

As a neonicotinoid pesticide, imidacloprid kills insects by irreversibly binding to nicotinic acetyl choline receptors, heavily interfering with neuronal transmission which can kill an insect at high doses. Due to this high level of specificity however mechanisms of resistance have evolved, most notably in the whitefly, possessing this variant of CYP6CM1. Capable of hydroxylating the 5th carbon of imidacloprid faster than other variants, CYP6CM!vQ bestows a partially protective effect against imidacloprid for an organism harboring this gene [1].


References

[1] Karunker, I., Morou, E., Nikou, D., Nauen, R., Sertchook, R., Stevenson, B. J., ... & Vontas, J. (2009). Structural model and functional characterization of the Bemisia tabaci CYP6CM1vQ, a cytochrome P450 associated with high levels of imidacloprid resistance. Insect biochemistry and molecular biology, 39(10), 697-706.