Difference between revisions of "Part:BBa K1611004"

Revision as of 12:07, 16 September 2015

DEC-205

This is a scFv antibody against DEC205. DEC205 is an endocytic receptor that is expressed by dendritic cells. Antigen endocytosed via DEC205 enters the MHC class I and MHC class II antigen presentation pathways and is subsequently presented to both CD4+ and CD8+ T cells. We used it to activate T-CD8 cells, with tumorous antigen that we binded to DEC205 scFv.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
INCOMPATIBLE WITH RFC[21]
Illegal BamHI site found at 533
Illegal XhoI site found at 414
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 2: / Line 2: @@
 <partinfo>BBa_K1611004 short</partinfo>
-This is a scFv antibody against CD205. DEC205 is an endocytic receptor that is expressed by dendritic cells.
+This is a scFv antibody against DEC205. DEC205 is an endocytic receptor that is expressed by dendritic cells.
-Antigen endocytosed via DEC205 enters the MHC class I and MHC class II antigen presentation pathways and is subsequently presented to both CD4+ and CD8+ T cells. We used it to activate T-CD8 cells, with tumorous antigen that we binded to.
+Antigen endocytosed via DEC205 enters the MHC class I and MHC class II antigen presentation pathways and is subsequently presented to both CD4+ and CD8+ T cells. We used it to activate T-CD8 cells, with tumorous antigen that we binded to DEC205 scFv.
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