Difference between revisions of "Part:BBa K1613005"

 
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<partinfo>BBa_K1613005 short</partinfo>
 
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cyp1a2 can oxidize the substances that it can metabolism.
 
cyp1a2 can oxidize the substances that it can metabolism.
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Cytochrome P450 1A2 is a member of the cytochrome P450 mixed-function oxidase system. And it is involved in the metabolism of xenobiotics in the body.
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Function  The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP1A2 is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include aflatoxin B1, and acetaminophen.
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Substrates
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many antidepressants          some atypical antipsychotics
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      amitriptyline                clozapine
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      clomipramine                  olanzapine                                                                        ropivacaine
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theophylline                  zolmitriptan[
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melatonin                    tamoxifen
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erlotinib                    cyclobenzaprine
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estradiol                    fluvoxaminemexiletine
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naproxen                      ondansetron
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phenacetin                    paracetamol
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propranolol                  riluzole
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tacrine                      tizanidine
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verapamil                    warfarin[
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<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here

Revision as of 03:17, 15 September 2015

A composite part that can detect some toxins.

cyp1a2 can oxidize the substances that it can metabolism.

Cytochrome P450 1A2 is a member of the cytochrome P450 mixed-function oxidase system. And it is involved in the metabolism of xenobiotics in the body. Function The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP1A2 is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include aflatoxin B1, and acetaminophen.


Substrates many antidepressants some atypical antipsychotics 

     amitriptyline                 clozapine
     clomipramine                  olanzapine                                                                        ropivacaine

theophylline zolmitriptan[ melatonin tamoxifen erlotinib cyclobenzaprine estradiol fluvoxaminemexiletine naproxen ondansetron phenacetin paracetamol propranolol riluzole tacrine tizanidine verapamil warfarin[


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 7
    Illegal NheI site found at 30
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 1464
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 384
    Illegal NgoMIV site found at 471
    Illegal AgeI site found at 454
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 1184