Difference between revisions of "Part:BBa K1110003"

Revision as of 23:53, 24 August 2015

Mambalgin-1 cDNA

Codes for the peptide Mambalgin-1, an analgesic

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

CTGAAATGTTACCAACATGGTAAAGTTGTGACTTGTCATCGAGATATGAAGTTTTGCTATCATAACACTGGCATGCCTTTTCGAAATCTCAAGCTCATCCTACAGGGATGTTCTTCTTCGTGCAGTGAAACAGAAAACAATAAGTGTTGCTCAACAGACAGATGCAACAAA

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 __NOTOC__
 <partinfo>BBa_K1110003 short</partinfo>
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 <!-- Add more about the biology of this part here
 ===Usage and Biology===
+Mambalgin is a protein component of the venom of Dendroaspis polylepis, better known as the Black Mamba.   Mambalgin-1 peptide that is a powerful analgesic that directly blocks pain transmission in the peripheral nervous system (Diochot et al, 2012) by targeting acid-sensing ion channels within nociceptors beneath the epidermis. Because Mambalgin acts on pain receptors within the skin rather than on opioid receptors in the brain, this peptide has great potential as a medication for pain treatment that is non-addicting and non-habit forming. Furthermore, recombinant purification of Mambalgin could assist in developing anti-venom without the attendant risk of harvesting venom directly from snakes.
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 <partinfo>BBa_K1110003 SequenceAndFeatures</partinfo>
+CTGAAATGTTACCAACATGGTAAAGTTGTGACTTGTCATCGAGATATGAAGTTTTGCTATCATAACACTGGCATGCCTTTTCGAAATCTCAAGCTCATCCTACAGGGATGTTCTTCTTCGTGCAGTGAAACAGAAAACAATAAGTGTTGCTCAACAGACAGATGCAACAAA
 <!-- Uncomment this to enable Functional Parameter display