Difference between revisions of "Part:BBa K1104300"
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<partinfo>BBa_K1104300 short</partinfo> | <partinfo>BBa_K1104300 short</partinfo> | ||
| − | Abaecin is a kind of antimicrobial peptides of honey bees(western & eastern). | + | <p> Abaecin is a kind of antimicrobial peptides of honey bees(western & eastern).</p> |
| + | ==''Working Mechanism(the same as normal antimicrobial peptides)''== | ||
| + | <p> The cytoplasmic membrane is a frequent target, but peptides may also interfere with DNA and protein synthesis, protein folding, and cell wall synthesis. The initial contact between the peptide and the target organism is electrostatic, as most bacterial surfaces are anionic, or hydrophobic. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by ‘barrel-stave’, ‘carpet’ or ‘toroidal-pore’ mechanisms. Alternately, they may penetrate into the cell to bind intracellular molecules which are crucial to cell living. Intracellular binding models includes inhibition of cell wall synthesis, alteration of the cytoplasmic membrane, activation of autolysin, inhibition of DNA, RNA, and protein synthesis, and inhibition of certain enzymes. One emerging technique for the study of such mechanisms is dual polarisation interferometry. In contrast to many conventional antibiotics these peptides appear to be bactericidal instead of bacteriostatic.</p> | ||
| + | [[File:NYMU_Group6_AMP-1.png|350px]] [[File:NYMU Group6 AMP-2.png|350px]] | ||
| + | |||
| + | *See more("articles & pictures" modified from) [http://en.wikipedia.org/wiki/Antimicrobial_peptides http://en.wikipedia.org/wiki/Antimicrobial_peptides] | ||
<!-- Add more about the biology of this part here | <!-- Add more about the biology of this part here | ||
===Usage and Biology=== | ===Usage and Biology=== | ||
Revision as of 06:26, 5 October 2013
Abaecin
Abaecin is a kind of antimicrobial peptides of honey bees(western & eastern).
Working Mechanism(the same as normal antimicrobial peptides)
The cytoplasmic membrane is a frequent target, but peptides may also interfere with DNA and protein synthesis, protein folding, and cell wall synthesis. The initial contact between the peptide and the target organism is electrostatic, as most bacterial surfaces are anionic, or hydrophobic. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by ‘barrel-stave’, ‘carpet’ or ‘toroidal-pore’ mechanisms. Alternately, they may penetrate into the cell to bind intracellular molecules which are crucial to cell living. Intracellular binding models includes inhibition of cell wall synthesis, alteration of the cytoplasmic membrane, activation of autolysin, inhibition of DNA, RNA, and protein synthesis, and inhibition of certain enzymes. One emerging technique for the study of such mechanisms is dual polarisation interferometry. In contrast to many conventional antibiotics these peptides appear to be bactericidal instead of bacteriostatic.
- See more("articles & pictures" modified from) [http://en.wikipedia.org/wiki/Antimicrobial_peptides http://en.wikipedia.org/wiki/Antimicrobial_peptides]
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]