Difference between revisions of "Part:BBa K1104200"
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===Introduction=== | ===Introduction=== | ||
| + | The Escherichia coli OxyR transcription factor senses | ||
| + | H<sub>2</sub>O<sub>2</sub> to activate transcription, and is activated through the formation of an intramolecular disulfide bond. | ||
| + | ===Literature Study of OxyR=== | ||
[[File: NYMU_OxyRactive.png|frame|center|'''Illustration of OxyR Activation''']] | [[File: NYMU_OxyRactive.png|frame|center|'''Illustration of OxyR Activation''']] | ||
OxyR, a positive regulator of hydrogen peroxide-inducible genes in ''E. coli''. | OxyR, a positive regulator of hydrogen peroxide-inducible genes in ''E. coli''. | ||
Revision as of 15:52, 30 September 2013
OxyR
Introduction
The Escherichia coli OxyR transcription factor senses H2O2 to activate transcription, and is activated through the formation of an intramolecular disulfide bond.
Literature Study of OxyR
Illustration of OxyR Activation
OxyR, a positive regulator of hydrogen peroxide-inducible genes in E. coli. The OxyR transcription factor regulates the H2O2 response of E. coli. H2O2 oxidizes OxyR Cys199 to an R-SOH that reacts with Cys208 in an intramolecular disulphide bond.
- Reference: D'Autréaux, B., & Toledano, M. B. (October 01, 2007). ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nature Reviews Molecular Cell Biology, 8, 10, 813-824.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]