Difference between revisions of "Part:BBa K1228009"

Revision as of 09:45, 27 September 2013

38aa and 25aa fusion peptide with T1 terminator and Constitutive promoter veg

Human lysozyme (hLZ), the major protein in breast milk, exhibits microbicidal activity to various degrees against several bacterial strains. The HLH peptide and its N-terminal helix (H1) were the most potent bactericidal to bacteria. Evidence shows that HLH peptide and its N-terminal helix (H1) kill bacteria by crossing the outer membrane of Gram-negative bacteria via self-promoted uptake and is able to dissipate the membrane-potential-dependent respiration of Gram-positive bacteria. Lactoferrin (Lf) is a multifunctional member of the transferrin. Lf is found at the mucosal surface where it functions as a prominent component of the first line of the host defense system against infection and inflammation. This protein has a broad spectrum of anti-infection and anti-inflammatory function. Also, lactoferrin has a broad anti-bacterial range and strong anti-bacterial activity.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

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 __NOTOC__
 <partinfo>BBa_K1228009 short</partinfo>
-Human lysozyme (hLZ), the actual protein in breast milk,exhibits microbicidal activity to various degrees against several bacterial strains.The HLH peptide and its N-terminal helix (H1) were significantly the most potent bactericidal to Gram-positive and Gram-negative bacteria.Evidence shows that HLH peptide and its N-terminal helix (H1) kill bacteria by crossing the outer membrane of Gram-negative bacteria via self-promoted uptake and are able to dissipate the membrane potential-dependent respiration of Gram-positive bacteria.
+Human lysozyme (hLZ), the major protein in breast milk, exhibits microbicidal activity to various degrees against several bacterial strains. The HLH peptide and its N-terminal helix (H1) were the most potent bactericidal to bacteria. Evidence shows that HLH peptide and its N-terminal helix (H1) kill bacteria by crossing the outer membrane of Gram-negative bacteria via self-promoted uptake and is able to dissipate the membrane-potential-dependent respiration of Gram-positive bacteria.
-Lf (loctoferrin) is located in many key body fluids , e.g., milk, tears, saliva and other secretions, and in white blood cells ,it has become clear that it is an important part of mammalian defence mechanisms, with a wide range of protective functions.25 amino acid residues is from Lf but has a strong bactericidal, bacteriostatic ability, and the antimicrobial activity than natural LF.
+Lactoferrin (Lf) is a multifunctional member of the transferrin. Lf is found at the mucosal surface where it functions as a prominent component of the first line of the host defense system against infection and inflammation. This protein has a broad spectrum of anti-infection and anti-inflammatory function. Also, lactoferrin has a broad anti-bacterial range and strong anti-bacterial activity.
 <!-- Add more about the biology of this part here