Difference between revisions of "Part:BBa K1228002"

 
 
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<partinfo>BBa_K1228002 short</partinfo>
 
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The glycoprotein is the main protective antigen of rabies virus, can induce the body to produce neutralizing antibody
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The RNA genome of the virus encodes five genes whose order is highly conserved. These genes code for nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and the viral RNA polymerase (L).The complete genome sequences range from 11,615 to 11,966 nt in length. Because of containing the neutralizing epitopes which are the targets of vaccine-induced immunity, the glycoprotein can stimulate the organism to produce antibody against Rabies.
  
  
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<partinfo>BBa_K1228002 parameters</partinfo>
 
<partinfo>BBa_K1228002 parameters</partinfo>
 
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== Acknowledge ==
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Associate professor MinCui provided the glycoprotein coding gene for us. We are grateful to her. The following is her homepage. http://my.hzau.edu.cn/Article/ShowArticle.asp?ArticleID=1831
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== References ==
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1. Morimoto K, Hooper DC, Spitsin S, et al. Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures. J Virol, 1999; 73, 510‐8.
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2. http://en.wikipedia.org/wiki/Rabies_virus

Latest revision as of 08:20, 27 September 2013

Rabies virus strain ERA glycoprotein coding sequence

The RNA genome of the virus encodes five genes whose order is highly conserved. These genes code for nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and the viral RNA polymerase (L).The complete genome sequences range from 11,615 to 11,966 nt in length. Because of containing the neutralizing epitopes which are the targets of vaccine-induced immunity, the glycoprotein can stimulate the organism to produce antibody against Rabies.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal XhoI site found at 510
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 1338
    Illegal BsaI site found at 1357
    Illegal BsaI.rc site found at 1564


Acknowledge

Associate professor MinCui provided the glycoprotein coding gene for us. We are grateful to her. The following is her homepage. http://my.hzau.edu.cn/Article/ShowArticle.asp?ArticleID=1831


References

1. Morimoto K, Hooper DC, Spitsin S, et al. Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures. J Virol, 1999; 73, 510‐8.

2. http://en.wikipedia.org/wiki/Rabies_virus