Difference between revisions of "Part:BBa K1151000"

Revision as of 12:22, 26 September 2013

Nickel-responsive pleiotropic regulator (HpNikR)

The HpNikR protein is a pleiotropic regulator from Helicobacter pylori. In presence of nickel it can acts as an activator or a repressor depending of the specific promoter that contains its operator site. It consists of two dimeric DNA binding domains separated by a tetrameric regulatory domain that binds nickel. This domain corresponds to the C-terminal regulatory domain which contains four nickel binding sites at the tetramer interface. Binding nickel, then a conformational change allows it to activate or repress trascription.

Usage and Biology

Figure 1: HpNikR nickel-binding domain (tetramer).

Figure 2: Proteic sequence analysis with Uniprot.

Safety

Sequence and Features