Difference between revisions of "Part:BBa K861400"
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For a E.coli to degrade fatty acid, at least four enzymes – FadA, FadB, FadD, FadE  
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For a E.coli to degrade fatty acid, at least four enzymes – FadA, FadB, FadD, FadE and transporter—FadL are needed. Long chain fatty acids(FAs) are firstly being imported by the transmembrane protein FadL. After FAs get into cells, they will be added a CoA by inner membrane-associated FadD (acyl-CoA synthase). β-oxidation is initiated by FadE(acyl-CoA dehydrogenase), which will convert acyl-CoA into enoyl-CoA. The followed cycles of hydration, oxidation, and thiolytic cleavage are carried out by tetrameric complex consisting of two FadA and two FadB proteins.
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and transporter—FadL are needed. Long chain fatty acids(FAs) are firstly being imported
+
−
by the transmembrane protein FadL. After FAs get into cells, they will be added a CoA
+
−
by inner membrane-associated FadD (acyl-CoA synthase). β-oxidation is initiated by
+
−
FadE(acyl-CoA dehydrogenase), which will convert acyl-CoA into enoyl-CoA. The followed cycles
+
−
of hydration, oxidation, and thiolytic cleavage are carried out by tetrameric complex consisting
+
−
of two FadA and two FadB proteins.
+

Revision as of 11:44, 16 August 2012

For a E.coli to degrade fatty acid, at least four enzymes – FadA, FadB, FadD, FadE and transporter—FadL are needed. Long chain fatty acids(FAs) are firstly being imported by the transmembrane protein FadL. After FAs get into cells, they will be added a CoA by inner membrane-associated FadD (acyl-CoA synthase). β-oxidation is initiated by FadE(acyl-CoA dehydrogenase), which will convert acyl-CoA into enoyl-CoA. The followed cycles of hydration, oxidation, and thiolytic cleavage are carried out by tetrameric complex consisting of two FadA and two FadB proteins.