View source for Part:BBa K4165234


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<partinfo>BBa_K4165234 short</partinfo>

Clamp [16] composed of Tau Binding Peptide WWW ( BBa_K4165007) , linker length of GGSGGGG (BBa_K4165018), Tau Binding Peptide TD28rev (BBa_K4165006). Our Clamp design was based on our project aim for binding with Tau and amyloid beta for further degradation.


===Usage and Biology===
According to Previous Research results, Our binding peptides proved to have dual effect of binding to both Tau and amyloid beta . According to this , we designed our clamps consists of various linker lengths and peptides parts for further  validation of this theory and analysis by wet-lab and dry lab results. According to our project Criteria , our clamps supposed to have binding affinity for tau and amyloid beta higher enough to make the inhibitor (BBa_K4165008) , (BBa_K4165010)  unbind from catalytic domain of HTRA1 protease system (BBa_K4165004).

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<span class='h3bb'>Sequence and Features</span>
<partinfo>BBa_K4165234 SequenceAndFeatures</partinfo>


===3D Modeling and Ranking ===
According to Previous Research results, Our binding peptides proved to have dual effect of binding to both Tau and amyloid beta . According to this , we designed our clamps consists of with various linker lengths and peptides parts for further validation of this theory and analysis by wet-lab and dry lab results. According to our project Criteria , our clamps supposed to have binding affinity for tau and amyloid beta higher enough to make the inhibitor (BBa_K4165008) , (BBa_K4165010) unbind from catalytic domain of HTRA1 protease system (BBa_K4165004).


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<p><img src="https://static.igem.wiki/teams/4165/wiki/parts-registry/16.png" style="margin-left:200px;" alt="" width="500" /></p>
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                               Figure 1. The 3D structure of Clamp 16 modeled by TRrosetta





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===Functional Parameters===
<partinfo>BBa_K4165234 parameters</partinfo>
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