Part:BBa_K3003026

Single Chain Insulin-57 with a linker peptide (SCI 57 Linker)

We took SCI-57 design from the study “Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications” done by Hua QX et al. SCI-57 differs from other single chain insulin analogs by modification in isoelectric points of determined amino acids and it was aimed for isoelectric points to be near as insulin. Linker we have used between SCI57's b and a chain was SCI57’s own linker. This linker is produced for SCI57 to provide more bioactivity and affinity for SCI57 to recognized by the receptor, therefore it increases the affinity of SCI for binding to insulin receptor in a more efficient way.