Part:BBa_K2496001
DPP4
The protein encoded by the DPP4 gene is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. It is a rather indiscriminate enzyme for which a diverse range of substrates are known. The substrates of CD26/DPPIV are proline(or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. Furthermore, it appears to work as a suppressor in the development of cancer and tumours.DPP-4 also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established. Team TNCR-Korea is focusing on the intestinal bacteria (Gut microflora) and has set hypothesis that introducing the DPP4 gene into intestinal bacteria of gluten sensitivity people.
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 724
Illegal PstI site found at 1498 - 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 1714
Illegal NheI site found at 2215
Illegal PstI site found at 724
Illegal PstI site found at 1498 - 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 2141
Illegal BamHI site found at 1 - 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 724
Illegal PstI site found at 1498 - 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 724
Illegal PstI site found at 1498 - 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI site found at 635
Illegal BsaI site found at 2002
| None |