DNA

Part:BBa_K5017003

Designed by: Christos Kalogeropoulos   Group: iGEM23_Patras-Med   (2023-10-11)


CD8a Hinge domain

CD8a Hinge domain: is a critical structural element within the CD8α protein. This hinge domain serves as a flexible linker between the CD8α protein's extracellular antigen-binding domain and its transmembrane region, allowing for the necessary conformational changes that occur during T-cell receptor (TCR) interactions with major histocompatibility complex (MHC) molecules on antigen-presenting cells. These dynamic structural adaptations are essential for the flexibility of the scFv domain of the CAR.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None