Part:BBa_K4880001
SaSS
This gene encodes for the santalene synthase derived from Santalum album and has been codon optimized in cyanobacteria. This sesquiterpene synthase converts farnesyl pyrophosphate to santalene.
Santalene
Santalene and its derivative Santalol(which has an additional oxygen, forming a hydroxyl group), is an organic chemical with formula of C15H24(C15H24O for Santalol), and is a pale yellow, slightly water soluble compound with a jaw-dropping market value of about 150,000 USD per Kilogram. The fragrance is woody (since it comes from the heartwood of Tropical Sandalwood) and is commonly used in Aromatherapy to prevent inflammation. It is also noted for its ability to induce cell apoptosis for cancer cells. However, as the high price tag might have implied already, the sandalwood tree which the fragrance comes from is extremely endangered: 175 years of commercial harvesting, grazing of saplings by livestock, climate change and poaching may have decreased the population of wild sandalwood by as much as 90%.
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 862
- 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 862
- 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 862
- 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 862
Illegal AgeI site found at 823
Illegal AgeI site found at 1462 - 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI site found at 1257
References
Blanc-Garin V, Chenebault C, Diaz-Santos E, Vincent M, Sassi JF, Cassier-Chauvat C, Chauvat F. Exploring the potential of the model cyanobacterium Synechocystis PCC 6803 for the photosynthetic production of various high-value terpenes. Biotechnol Biofuels Bioprod. 2022 Oct 14;15(1):110.
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