Part:BBa_K3619011

Gene scar, encoding the antimicrobial peptide Scarabaecin.

The scar gene, encoding the antimicrobial peptide scarabaecin which possesses antifungal activity towards a variety of pathogens. However, is it not toxic against bacteria. The antifungal activity is achieved by interference if the cell membrane through chitin-binding [1].

The half maximal inhibitory concentration (IC50) for fungi and oomycetes normally was ranging from 4 to 32 uM, but for the species Phytophthora infestans and aphanidermatum it was above 250uM. IC50 for bacteria was above 100uM for all expect one tested species [2].

Scarabaecin was isolated from the hemolymph of Oryctes rhinoceros, Coconut rhinoceros beetle. The protein has one disulfide bridge [3].

For more information of the peptide, see Uniprot record Q86SC0

Sources:

1. https://www.uniprot.org/uniprot/Q86SC0

2. https://www.sciencedirect.com/science/article/abs/pii/S0006291X03011628

3. https://pubmed.ncbi.nlm.nih.gov/12676931/

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]