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Translational_Unit
ComD

Part:BBa_K316015

Designed by: IC 2010 Team   Group: iGEM10_Imperial_College_London   (2010-10-20)

ComD receptor for CSP-1 (S. pneumoniae), phosphorylates ComE


ComD is the histidine kinase of a two-component signal transduction signaling pathway in a Streptococcus pneumoniae quorum sensing system. It detects the linear autoinducing peptide (AIP) called Competence-Stimulating Peptide-1 (CSP-1)[1] which is coded for by the comC gene. ComD is sensitive to ComC concentrations as low as 2-10 ng/ul[2]. Upon detection of CSP-1, ComD will autophosphoylate and then phosphorylate and activate the response regulator, ComE BBa_K316016.


For more information on ComCDE system, please check our wiki


Sequence and Features

Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 1363
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


References

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Parameters
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