SARS Coronavirus Envelope Protein
This part is SARS Coronavirus Envelope Protein, abbreviated as SCVE. The protein will improve the bactial permeability, which is one of the strategy of permeability improvement originally inplemented in USTC 2015.
SCVE, the abbreviation of SARS Caronavirus Envolope protein,is a kind of effective viroporin(viroporins are similar to porins in that they oligomerize within the membrane to form pores and this oligomerization often occurs between hydrophobic, transmembrane and alpha-helical domains of the proteins) within 76 residues that is found normally pentamerized in bacteria. SCVE is permeable for many small molecules, which is originately designed for apoptosis of cells triggered by virus. Implementation of SCVE in ROSE may potentially improve the permeability of small molecules including antibiotics.
We had already done the polymerase chain reaction (PCR) of SCVE successfully.
1. Model of a putative pore: the pentameric alpha-helical bundle conronavirus E protein in lipid bilayers Biophysics(2006) DX Liu.
2. SARS coronavirus E protein forms cation-selective ion channel Virology(2004) Gary Ewart. Sequence and Features