AcrAB-TolC multidrug efflux transport system activator from E. coli
The MarA protein acts as a transcriptional activator in E. coli, it allows the expression of the acrAB and tolC operons, which activate the AcrAB-TolC efflux pump, a mechanism that has been related with resistance to organic solvents, dyes, detergents, antibiotics such as chloramphenicol, tetracycline, novobiocin, erythromycin, fusidic acid and cloxacillin, as well as to cationic antimicrobial peptides, such as LL-37, HNP-2 and HBD-1.
We used device BBa_K1230004 to characterise this part.
Team Nagahama 2016
We improved the characterization of existing this Part BBa_K1230000. We found that marA expression is also improve resistance to farnesol. Please see our wiki result page ""Enhancement of farnesol resistance"".
Sequence and Features
- 10COMPATIBLE WITH RFC
- 12COMPATIBLE WITH RFC
- 21COMPATIBLE WITH RFC
- 23COMPATIBLE WITH RFC
- 25Illegal AgeI site found at 154
- 1000COMPATIBLE WITH RFC
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