Coding

Part:BBa_I10888

Designed by: Tracy Chang   Group: BE.109 2006 BE.109 Instructors   (2006-04-25)


Human Tyrosine Kinase Receptor(TrkA)

This gene encodes a member of the neurotrophic tyrosine 

          kinase receptor (NTKR) family. This kinase is a membrane-bound

          receptor that, upon neurotrophin binding, phosphorylates itself and

          members of the MAPK pathway. The presence of this kinase leads to

          cell differentiation and may play a role in specifying sensory

          neuron subtypes. Mutations in this gene have been associated with

          congenital insensitivity to pain, anhidrosis, self-mutilating

          behavior, mental retardation and cancer. Alternate transcriptional

          splice variants of this gene have been found, but only three have

          been characterized to date.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 1947
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 2212
    Illegal BamHI site found at 736
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 729
    Illegal NgoMIV site found at 980
    Illegal NgoMIV site found at 1058
    Illegal NgoMIV site found at 2451
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 360
    Illegal BsaI site found at 881
    Illegal BsaI site found at 1307
    Illegal BsaI.rc site found at 1026
    Illegal BsaI.rc site found at 1071
    Illegal BsaI.rc site found at 1270
    Illegal SapI site found at 1001


[edit]
Categories
Parameters
None